The Molecular Anatomy of Spontaneous Germline Mutations in Human Testes
Figure 3
The models are depicted with only three growth phase generations leading to eight adult SrAp cells; in actuality there are ∼30 growth phase generations leading to ∼1010 adult SrAp cells. The vertical tick marks across the top line depict adult phase generations; for the donors in this paper there are ∼1,000 adult phase generations. (A) Mutation hot spot model (p = 0). There are two mutation events (red crosses): one is in the adult phase which produces one mutated SrAp cell, while the other one in the growth phase produces four mutated SrAp cells. (B) Selection model (p > 0). The one mutation in the adult phase now produces three mutated SrAp cells.