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A New Approach for Using Genome Scans to Detect Recent Positive Selection in the Human Genome

Figure 5

Power of the Two ln(Rsb)-Based Tests for Different Values of f (the Strength of the Bottleneck Experienced by the Derived Population)

(A) The power plot for test I, which uses ratio of tSNPs as the test statistic (see Methods). The critical value is set by independent neutral simulation at a level of 0.01. Curves in red show the power to detect selection that occurs in the central 1 Mb. Curves in blue show the power to detect selection that occurs outside the central 1 Mb, but within 200 kb. Dashed curves in green are the overall power for the entire simulated 2-Mb segment.

(B) The power plot for test II, the ad hoc test. A case is called significant only if the selected site lies within a candidate region.

Figure 5

doi: https://doi.org/10.1371/journal.pbio.0050171.g005