A KATP Channel-Dependent Pathway within α Cells Regulates Glucagon Release from Both Rodent and Human Islets of Langerhans
Figure 3
Tolbutamide and Glucose Effects Are Non-Additive and Glucagon Response Is Altered in Kir6.2Y12X Islets That Express a Truncated Kir6.2 Subunit
(A) Glucagon release from isolated mouse islets at 1 (open bars) and 20 mM glucose (filled bars) under control conditions and presence of 0.5 mM tolbutamide.
(B) A glucose dose-response of glucagon release from control C3HB islets (filled circles) and Kir6.2Y12X islets (open circles).
(C) As in (B), but insulin was measured.
*, p < 0.05; **, p < 0.01; ***, p < 0.001, compared with control.