Cyclin B1–Cdk1 Activation Continues after Centrosome Separation to Control Mitotic Progression
Figure 4
Schematic Representation of Cytoplasmic cyclin B1–Cdk1 Activation
Average ratio of Cdk1-P and cyclin B1 staining (black solid line), average estimated cyclin B1–Cdk1 activity (gray solid line), and average APC-3 S426-P (black dotted line) plotted as a function of time (x-axis). The duration of mitotic events is derived from measurements described in Figure S8. Note the decrease in total cytoplasmic activity, but not in the progression of cyclin B1–Cdk1 dephosphorylation, between centrosome separation and nuclear translocation of cyclin B1–Cdk1.