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Aging and Gene Expression in the Primate Brain

Figure 4

Aging in the Chimpanzee Brain

The abbreviations used are as follows: ACC, anterior cingulate cortex; C, cerebellum; PFC, prefrontal cortex.

(A) Correlations of aging gene expression patterns between all three possible pairs of the three regions of the chimpanzee brain used in this work (from left to right, number of genes used are 1,343, 2,235, and 1,328). The strong correlation when comparing cortex regions indicates a reproducible pattern of aging in chimpanzee cortex.

(B) Correlations of aging gene expression patterns between human frontal pole [7] and each of the three regions of the chimpanzee brain used in this work (841 genes used in each comparison). The lack of any significant correlation suggests that human and chimpanzee brain aging patterns differ.

Figure 4

doi: https://doi.org/10.1371/journal.pbio.0030274.g004