Advertisement

< Back to Article

Aging and Gene Expression in the Primate Brain

Figure 2

Aging in the Human Brain

The abbreviations used are as follows: ACC, anterior cingulate cortex; BA, Broca's area; C, cerebellum; CN, caudate nucleus; PFC, prefrontal cortex; PVC, primary visual cortex.

(A) Correlations of aging gene expression patterns between human frontal pole [7] and each of the six regions of the human brain from [19] (from left to right, number of genes used are 656, 733, 684, 710, 690, and 603). The strong correlation for all four cerebral cortex samples indicates a reproducible aging pattern across all tested regions of cortex; this pattern does not hold for caudate nucleus or cerebellum.

(B) Correlations of aging gene expression patterns between human prefrontal cortex [20] and each of the six regions of the human brain from [19] (from left to right, number of genes used are 704, 832, 697, 784, 759, and 674). The strong correlations for all four cortex samples indicates a reproducible aging pattern across all tested regions of cortex but not caudate nucleus or cerebellum, confirming the result of (A).

(C) Correlations of aging gene expression patterns between cerebellum [20] and each of the six regions of the brain from [19] (from left to right, number of genes used are 213, 241, 204, 241, 244, and 204). The lack of any significant correlation, even when comparing the two cerebellum aging patterns to each other, suggests that human cerebellum lacks a reproducible aging pattern.

Figure 2

doi: https://doi.org/10.1371/journal.pbio.0030274.g002