Neuronal Migration and Ventral Subtype Identity in the Telencephalon Depend on SOX1
Figure 8
The Distribution of VS Neurons Is Unaffected in Mice Over-Expressing SOX1 from the Sox2R Allele
(A–D), X-gal staining of coronal sections from the ventral telencephalon of P0 mice. Note that there is no difference in the distribution of Sox2-expressing OT neurons with SOX1 (A) or without SOX1 (C), and in Sox2R/+ mice with two wild-type Sox1 alleles (A) or one (B). Comparison of the number and distribution of neurons expressing Sox2βgeo in (C) and Sox1βgeo in (D) shows overlapping expression. (A–C) show 150-μm sections, and (D) shows a 80-μm section.
(E and F) DARPP-32 immunostaining of coronal sections from the ventral telencephalon of P10 Sox2R/+ and Sox1βgeo/+ single heterozygous mice, showing no difference in the generation and migration of OT neurons. AC, anterior commissure. Scale bar = 100 μm.