Inhibition of Mutation and Combating the Evolution of Antibiotic Resistance
Figure 1
Survival and Mutation of E. coli Mutants In Vivo after Starting Antibiotic Therapy
Survival and mutation of ΔlacZ and lexA(S119A) mutants of E. coli ATCC 25922 in thighs of neutropenic mice at 24-h intervals after starting therapy with (A) ciprofoxacin or (B) rifampicin. Open circles and triangles correspond to the total cfu/thigh of the ΔlacZ and lexA(S119A) strains, respectively. Solid circles and triangles represent the number of drug-resistant ΔlacZ and lexA(S119A) cfu/thigh, respectively.