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Three-Dimensional Maps of All Chromosomes in Human Male Fibroblast Nuclei and Prometaphase Rosettes

Figure 5

Significance Levels for Pairwise Comparisons of 3D Distance Measurements Performed in 54 G0 Fibroblast Nuclei and in 50 SCD Model Nuclei

Significance levels determined by the two-tailed K-S test are indicated by colors. Green, not significant, p > 0.01; yellow, p < 0.01; orange, p < 0.001; red, p < 0.0001. A minus (or plus) sign in a colored field indicates that the 3D CN–CT (A and B) or 3D CT–CT distance (C and D) indicated at the left (row) revealed a significantly shorter (or greater) mean radial distance than the CT indicated at the top (column).

(A) Comparison of 3D CN–CT distances in G0 fibroblast nuclei.

(B) Comparison of 3D CT–CN distances in fibroblast nuclei (vertical row) with 3D CN–CT distances in SCD model nuclei (horizontal row).

(C) Comparison of 3D CT–CT distances between homologous chromosomes in G0 fibroblast nuclei.

(D) Comparison of 3D CT–CT distances between homologous chromosomes in SCD model nuclei.

Figure 5

doi: https://doi.org/10.1371/journal.pbio.0030157.g005