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Aging and Death in an Organism That Reproduces by Morphologically Symmetric Division

Figure 3

The Effects of Consecutive Divisions as an Old or New Pole on Growth Rate

(A) The cellular growth rate, represented on the y-axis, is normalized to the growth rate of all cells from the same generation and geography in each film. On the x-axis consecutive divisions are seen as either a new pole (open circles), showing rejuvenation, or an old pole (closed circles), showing aging. Cells represented at each point: new pole divisions 1–7: 7,730; 3,911; 1,956; 984; 465; 211; 89; old pole divisions 1–7: 4,687; 3,833; 1,933; 956; 465; 213; 75.

(B) Pair comparison of the growth rates of sibling cells. The division age of the old pole sibling (the mother cell) is shown on the x-axis. The percentage difference between the growth rate of the new pole sibling (the daughter cell) and this cell is shown on the y-axis. A positive difference corresponds to a faster growth rate for the new pole cell. Cell pairs represented at each point, ages 1–7: 9,722; 4,824; 2,409; 1,202; 601; 282; 127.

In both graphs, cells are from all 94 films. The error bars represent the standard error of the mean. The old and new pole growth rates in (A) and the pair differences in (B) are fitted to a line to show the trend; however, the actual progressions may not be linear (R2 old poles = 0.97, new poles = 0.83, pair difference = 0.94).

Figure 3