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Posted by bethmolnar on 21 Jun 2013 at 14:02 GMT

Laminins seem also involved at the nuclear level: in Progeria or Hutchinson-Gifford syndrome, mutated LaminA, which is farnesylated, is associated with distal and cardiac myopathycharacterized by for example, I understand there is a connection to the cytoskeletal system and to chromosomal material. Niacin is also a cofactor in cholesterol metabolism, again at a nuclear level perhaps, and perhaps other pathways as well as the Krebs. Various papers on such subjects are easily found.Thank you for your synopsis.

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