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key paper for everybody interested in EJC assembly and NMD

Posted by mueli on 19 Aug 2009 at 09:59 GMT

A remarkable paper. The high quality results of these elegant experiments allow absolutely compelling conclusions. The ordered splicing-dependent assembly of the eIF4A3-Y14-MAGOH pre-EJC followed by the splicing-independent association of BTZ and UPF3b has been elucidated and BTZ's role in NMD has been characterized.

No competing interests declared.