Firstly many congratulations on these guidelines. They should increase the value of the peer-reviewed litereture, the value of anmal experiments, and the return on funders' financial investment. I hope they are widely adopted.
An observation: as with all guidelines (I would suggest) there is a need for common sense in marginal cases. For example Paul Lauterbur's Nobel prize-winning mouse study (1) would not be in compliance, and arguably should not need to be brought into complete compliance were it publihed today.
(1) Lauterbur PC (1974). "Magnetic resonance zeugmatography". Pure and Applied Chemistry 40: 149–157. doi:10.1351/pac197440010149.
