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ERG mutations in C. tropicalis

Posted by Canadom on 07 Nov 2013 at 13:34 GMT

This is a quite remarkable paper. When looking at the ATTC AmB-resistant C. tropicalis isolate referred in this study, I observed that this ATCC strain was already investigated by Forastiero et al. (Antimicrobial Agents and Chemotherapy 2013. 57(10), 4769–4781). The authors found the same mutations that are reported in this Plos paper, just that the PLos paper report a 170-bp deletion in ERG11, while it is 132-bp in Forastiero et al, the last being more accurate. Strangely enough, another Amb-resistant C. tropicalis clinical isolate but of different geograpical origin was reported with exactly the same mutations than described by Forastiero et al. and this PLos paper (Eddouzi et al., Antimicrobial Agents and Chemotherapy, 2013, 57(7), 3182–3193). That two distinct clinical Candida isolates exhibit the same homozygous mutations on two different genes is quite unusual.

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