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Thiol status of receptors in vivo

Posted by pbio on 07 May 2009 at 22:15 GMT

Author: Richard Lanzara
Position: Pharmacologist
Institution: Bio Balance, Inc.
Submitted Date: December 30, 2006
Published Date: January 2, 2007
This comment was originally posted as a “Reader Response” on the publication date indicated above. All Reader Responses are now available as comments.

I’m trying to generate some cross-disciplinary interest in the fact that many, if not most, G protein-coupled receptors are thiol sensitive proteins.

Our proposal is that in vivo receptors exist as an equilibrium between oxidized (disulfide) and reduced (free thiol) forms (depending on the physiological REDOX milieu), but for many GPCRs, it is the reduced form that functions as the R and R* states.


Competing interests declared: Principal Scientific Officer, Bio Balance, Inc.