Protein Aggregation and Protein Instability Govern Familial Amyotrophic Lateral Sclerosis Patient Survival

Qi Wang; Joshua L Johnson; Nathalie Y.R Agar; Jeffrey N Agar

doi:10.1371/journal.pbio.0060170

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Open Access

Peer-reviewed

Research Article

Protein Aggregation and Protein Instability Govern Familial Amyotrophic Lateral Sclerosis Patient Survival

Qi Wang,

Affiliations Department of Chemistry, Brandeis University, Waltham, Massachusetts, United States of America , Volen Center, Brandeis University, Waltham, Massachusetts, United States of America
⨯
Joshua L Johnson,

Affiliations Volen Center, Brandeis University, Waltham, Massachusetts, United States of America , Department of Biochemistry, Brandeis University, Waltham, Massachusetts, United States of America
⨯
Nathalie Y.R Agar,

Affiliation Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Jeffrey N Agar

*To whom correspondence should be addressed. E-mail: agar@brandeis.edu

Affiliations Department of Chemistry, Brandeis University, Waltham, Massachusetts, United States of America , Volen Center, Brandeis University, Waltham, Massachusetts, United States of America
⨯

Protein Aggregation and Protein Instability Govern Familial Amyotrophic Lateral Sclerosis Patient Survival

Qi Wang,
Joshua L Johnson,
Nathalie Y.R Agar,
Jeffrey N Agar

Published: July 29, 2008
https://doi.org/10.1371/journal.pbio.0060170

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Posted by PLOSBiology on 07 May 2009 at 22:26 GMT

Author: Graham Steel
Position: Co-Founder
Institution: CJD Alliance
E-mail: steelgraham@hotmail.com
Submitted Date: July 29, 2008
Published Date: August 6, 2008
This comment was originally posted as a “Reader Response” on the publication date indicated above. All Reader Responses are now available as comments.

I wish to thank the authors for the preparation and publication of this Manuscript on an Open Access Journal like PLoS Biology.

There is some discussion about it on the following thread on the ALS Therapy Development Institutes Forum:- http://www.als.net/forum/...

If any of the authors wish to leave a comment, please do so either here, over at the ALSTDI Forum or via myself and if I have your permission, I'll post this onto the Forum on their behalf.

Many thanks,

Graham Steel

No competing interests declared.

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Amyotrophic lateral sclerosis
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Point mutation
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Protein aggregation
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Protein Aggregation and Protein Instability Govern Familial Amyotrophic Lateral Sclerosis Patient Survival

Protein Aggregation and Protein Instability Govern Familial Amyotrophic Lateral Sclerosis Patient Survival

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Posted by PLOSBiology on 07 May 2009 at 22:26 GMT