The Evolutionary Consequences of Blood-Stage Vaccination on the Rodent Malaria Plasmodium chabaudi

Victoria C. Barclay; Derek Sim; Brian H. K. Chan; Lucas A. Nell; Maia A. Rabaa; Andrew S. Bell; Robin F. Anders; Andrew F. Read

doi:10.1371/journal.pbio.1001368

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Open Access

Peer-reviewed

Research Article

The Evolutionary Consequences of Blood-Stage Vaccination on the Rodent Malaria Plasmodium chabaudi

Victoria C. Barclay ,

* E-mail: vcb11@psu.edu

Affiliation Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America
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Derek Sim,

Affiliation Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America
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Brian H. K. Chan,

Affiliation Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America
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Lucas A. Nell,

Affiliation Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America
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Maia A. Rabaa,

Affiliation Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America
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Andrew S. Bell,

Affiliation Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America
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Robin F. Anders,

Affiliation Department of Biochemistry, La Trobe University, Melbourne, Australia
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Andrew F. Read

Affiliations Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America, Department of Entomology, The Pennsylvania State University, University Park, Pennsylvania, United States of America, Fogarty International Center, National Institutes of Health, Bethesda, Maryland, United States of America
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The Evolutionary Consequences of Blood-Stage Vaccination on the Rodent Malaria Plasmodium chabaudi

Victoria C. Barclay,
Derek Sim,
Brian H. K. Chan,
Lucas A. Nell,
Maia A. Rabaa,
Andrew S. Bell,
Robin F. Anders,
Andrew F. Read

Published: July 31, 2012
https://doi.org/10.1371/journal.pbio.1001368

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Evolution of malarial virulance

Posted by Karthikg on 02 Aug 2012 at 09:07 GMT

Excellent Manuscript, just a few quick questions,

1) is this something that is peculiar with P.chabaudi, how would other virulant strains evolve..P.yeolii, P.berghei etc

2) I think that the caveat section is very intrestiong, I am not sure how good is the translatability to human situations is, if in the mouse model infection is for 7 days before the host immune system has had a go at it...

3) if the candidate sequence remains unchanged, could some kind of an epigenetic phenomenon throw light on what is happening in the evolved parasites

Keep up the good work

Karthik Ganesan

No competing interests declared.

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The Evolutionary Consequences of Blood-Stage Vaccination on the Rodent Malaria Plasmodium chabaudi

The Evolutionary Consequences of Blood-Stage Vaccination on the Rodent Malaria Plasmodium chabaudi

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Evolution of malarial virulance

Posted by Karthikg on 02 Aug 2012 at 09:07 GMT