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Evolution of malarial virulance

Posted by Karthikg on 02 Aug 2012 at 09:07 GMT

Excellent Manuscript, just a few quick questions,

1) is this something that is peculiar with P.chabaudi, how would other virulant strains evolve..P.yeolii, P.berghei etc

2) I think that the caveat section is very intrestiong, I am not sure how good is the translatability to human situations is, if in the mouse model infection is for 7 days before the host immune system has had a go at it...

3) if the candidate sequence remains unchanged, could some kind of an epigenetic phenomenon throw light on what is happening in the evolved parasites

Keep up the good work

Karthik Ganesan

No competing interests declared.