Novel Role of NOX in Supporting Aerobic Glycolysis in Cancer Cells with Mitochondrial Dysfunction and as a Potential Target for Cancer Therapy

• Weiqin Lu ,

  Contributed equally to this work with: Weiqin Lu, Yumin Hu

  Affiliation Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

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• Yumin Hu ,

  Contributed equally to this work with: Weiqin Lu, Yumin Hu

  Affiliations Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America, State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University Cancer Center, Guangzhou, China

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• Gang Chen,

  Affiliation Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

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• Zhao Chen,

  Affiliation Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

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• Hui Zhang,

  Affiliation Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

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• Feng Wang,

  Affiliations Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America, State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University Cancer Center, Guangzhou, China

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• Li Feng,

  Affiliation Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

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• Helene Pelicano,

  Affiliation Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

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• Hua Wang,

  Affiliation Department of GI Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

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• Michael J. Keating,

  Affiliation Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

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• Jinsong Liu,

  Affiliation Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

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• Wallace McKeehan,

  Affiliation Proteomics and Nanotechnology Laboratory, Center for Cancer and Stem Cell Biology, Institute of Biosciences and Technology, Texas A&M University Health Science Center, Houston, Texas, United States of America,

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• Huamin Wang,

  Affiliation Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

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• Yongde Luo,

  Affiliation Proteomics and Nanotechnology Laboratory, Center for Cancer and Stem Cell Biology, Institute of Biosciences and Technology, Texas A&M University Health Science Center, Houston, Texas, United States of America,

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• Peng Huang

  * E-mail: phuang@mdanderson.org

  Affiliation Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

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