Cellular and Molecular Bases of the Initiation of Fever

Alexandre A Steiner; Andrei I Ivanov; Jordi Serrats; Hiroshi Hosokawa; Allison N Phayre; Jared R Robbins; Jennifer L Roberts; Shigeo Kobayashi; Kiyoshi Matsumura; Paul E Sawchenko; Andrej A Romanovsky

doi:10.1371/journal.pbio.0040284

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Open Access

Peer-reviewed

Research Article

Cellular and Molecular Bases of the Initiation of Fever

Alexandre A Steiner,

Affiliation Systemic Inflammation Laboratory, Trauma Research, St. Joseph's Hospital and Medical Center, Phoenix, Arizona, United States of America
⨯
Andrei I Ivanov,

Affiliation Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, United States of America
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Jordi Serrats,

Affiliation Laboratory of Neuronal Structure and Function, The Salk Institute for Biological Studies, La Jolla, California, United States of America
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Hiroshi Hosokawa,

Affiliation Department of Intelligence Science and Technology, Graduate School of Informatics, Kyoto University, Kyoto, Japan
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Allison N Phayre,

Affiliation Systemic Inflammation Laboratory, Trauma Research, St. Joseph's Hospital and Medical Center, Phoenix, Arizona, United States of America
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Jared R Robbins,

Affiliation Systemic Inflammation Laboratory, Trauma Research, St. Joseph's Hospital and Medical Center, Phoenix, Arizona, United States of America
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Jennifer L Roberts,

Affiliation Systemic Inflammation Laboratory, Trauma Research, St. Joseph's Hospital and Medical Center, Phoenix, Arizona, United States of America
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Shigeo Kobayashi,

Affiliation Department of Intelligence Science and Technology, Graduate School of Informatics, Kyoto University, Kyoto, Japan
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Kiyoshi Matsumura,

Affiliation Osaka Institute of Technology, Hirakata-City, Osaka, Japan
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Paul E Sawchenko,

Affiliation Laboratory of Neuronal Structure and Function, The Salk Institute for Biological Studies, La Jolla, California, United States of America
⨯
Andrej A Romanovsky

*To whom correspondence should be addressed. E-mail: aromano@chw.edu

Affiliation Systemic Inflammation Laboratory, Trauma Research, St. Joseph's Hospital and Medical Center, Phoenix, Arizona, United States of America
⨯

Cellular and Molecular Bases of the Initiation of Fever

Alexandre A Steiner,
Andrei I Ivanov,
Jordi Serrats,
Hiroshi Hosokawa,
Allison N Phayre,
Jared R Robbins,
Jennifer L Roberts,
Shigeo Kobayashi,
Kiyoshi Matsumura,
Paul E Sawchenko

Published: August 22, 2006
https://doi.org/10.1371/journal.pbio.0040284

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Contradictory data

Posted by FeverLab on 19 Sep 2012 at 18:53 GMT

The in-press Endocrinology paper from Anders Blomqvist’s laboratory (http://www.ncbi.nlm.nih.g...) suggests that PGE2 that triggers fever – even the first (early) febrile phase – comes from brain endothelial cells. This new evidence does not support our conclusion (the 2006 PLoS Biology paper) about the peripheral origination (pulmonary and hepatic macrophages) of PGE2 triggering fever. Blomqvist and his coauthors propose a new pathogenetic sequel for fever, based on their new results and on our 2006 results reported in the journal Blood (http://www.feverlab.net/p...). Clearly, this topic needs more research.

No competing interests declared.

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Cellular and Molecular Bases of the Initiation of Fever

Cellular and Molecular Bases of the Initiation of Fever

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Contradictory data

Posted by FeverLab on 19 Sep 2012 at 18:53 GMT