TY - JOUR T1 - USP8 Promotes Smoothened Signaling by Preventing Its Ubiquitination and Changing Its Subcellular Localization A1 - Xia, Ruohan A1 - Jia, Hongge A1 - Fan, Junkai A1 - Liu, Yajuan A1 - Jia, Jianhang Y1 - 2012/01/10 N2 - Hedgehog regulates the activity of its signal transducer Smoothened by enhancing its interaction with the deubiquitinase USP8, thereby promoting Smoothened translocation to the cell surface and so enhancing Hh signaling. JF - PLOS Biology JA - PLOS Biology VL - 10 IS - 1 UR - https://doi.org/10.1371/journal.pbio.1001238 SP - e1001238 EP - PB - Public Library of Science M3 - doi:10.1371/journal.pbio.1001238 ER -