About the Authors

Brian P. Anton

Contributed equally to this work with: Brian P. Anton, Yi-Chien Chang

anton@neb.com (BPA); kasif@bu.edu (SK)

Affiliation New England Biolabs, Ipswich, Massachusetts, United States of America

Yi-Chien Chang

Contributed equally to this work with: Brian P. Anton, Yi-Chien Chang

Affiliation Bioinformatics Program, Boston University, Boston, Massachusetts, United States of America

Peter Brown

Affiliation Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America

Han-Pil Choi

Affiliation Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America

Lina L. Faller

Affiliation Bioinformatics Program, Boston University, Boston, Massachusetts, United States of America

Jyotsna Guleria

Affiliation Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America

Zhenjun Hu

Affiliation Bioinformatics Program, Boston University, Boston, Massachusetts, United States of America

Niels Klitgord

Affiliation Bioinformatics Program, Boston University, Boston, Massachusetts, United States of America

Ami Levy-Moonshine

Affiliation Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America

Almaz Maksad

Affiliation Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America

Varun Mazumdar

Affiliation Bioinformatics Program, Boston University, Boston, Massachusetts, United States of America

Mark McGettrick

Affiliation Diatom Software LLC, Holliston, Massachusetts, United States of America

Lais Osmani

Affiliation Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America

Revonda Pokrzywa

Affiliation Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America

John Rachlin

Affiliation Diatom Software LLC, Holliston, Massachusetts, United States of America

Rajeswari Swaminathan

Affiliation Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America

Benjamin Allen

Affiliations Program for Evolutionary Dynamics, Harvard University, Cambridge, Massachusetts, United States of America, Department of Mathematics, Emmanuel College, Boston, Massachusetts, United States of America

Genevieve Housman

Affiliation Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America

Caitlin Monahan

Affiliation Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America

Krista Rochussen

Affiliation Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America

Kevin Tao

Affiliation Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America

Ashok S. Bhagwat

Affiliation Department of Chemistry, Wayne State University, Detroit, Michigan, United States of America

Steven E. Brenner

Affiliation Department of Plant and Microbial Biology, University of California, Berkeley, California, United States of America

Linda Columbus

Affiliation Department of Chemistry, University of Virginia, Charlottesville, Virginia, United States of America

Valérie de Crécy-Lagard

Affiliation Department of Microbiology and Cell Science, University of Florida, Gainesville, Florida, United States of America

Donald Ferguson

Affiliation Department of Microbiology, Miami University, Oxford, Ohio, United States of America

Alexey Fomenkov

Affiliation New England Biolabs, Ipswich, Massachusetts, United States of America

Giovanni Gadda

Affiliation Department of Chemistry, Georgia State University, Atlanta, Georgia, United States of America

Richard D. Morgan

Affiliation New England Biolabs, Ipswich, Massachusetts, United States of America

Andrei L. Osterman

Affiliation Bioinformatics and Systems Biology, Sanford Burnham Medical Research Institute, La Jolla, California, United States of America

Dmitry A. Rodionov

Affiliation Bioinformatics and Systems Biology, Sanford Burnham Medical Research Institute, La Jolla, California, United States of America

Irina A. Rodionova

Affiliation Bioinformatics and Systems Biology, Sanford Burnham Medical Research Institute, La Jolla, California, United States of America

Kenneth E. Rudd

Affiliation Department of Biochemistry and Molecular Biology, University of Miami, Miami, Florida, United States of America

Dieter Söll

Affiliation Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America

James Spain

Affiliation School of Civil and Environmental Engineering, Georgia Institute of Technology, Atlanta, Georgia, United States of America

Shuang-yong Xu

Affiliation New England Biolabs, Ipswich, Massachusetts, United States of America

Alex Bateman

Affiliation European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, United Kingdom

Robert M. Blumenthal

Affiliation Department of Medical Microbiology and Immunology, and Program in Bioinformatics, University of Toledo, Toledo, Ohio, United States of America

J. Martin Bollinger

Affiliation Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, United States of America

Woo-Suk Chang

Affiliation Department of Biology, University of Texas-Arlington, Arlington, Texas, United States of America

Manuel Ferrer

Affiliation Spanish National Research Council (CSIC), Institute of Catalysis, Madrid, Spain

Iddo Friedberg

Affiliation Department of Microbiology, Miami University, Oxford, Ohio, United States of America

Michael Y. Galperin

Affiliation National Center for Biotechnology Information (NCBI), National Institutes of Health (NIH), Bethesda, Maryland, United States of America

Julien Gobeill

Affiliations Department of Library and Information Sciences, University of Applied Sciences Western Switzerland, Geneva, Switzerland, Bibliomics and Text Mining Group, Swiss Institute of Bioinformatics, Geneva, Switzerland

Daniel Haft

Affiliation J. Craig Venter Institute, Rockville, Maryland, United States of America

John Hunt

Affiliation Biological Sciences, Columbia University, New York, New York, United States of America

Peter Karp

Affiliation Bioinformatics Research Group, Artificial Intelligence Center, SRI International, Menlo Park, California, United States of America

William Klimke

Affiliation National Center for Biotechnology Information (NCBI), National Institutes of Health (NIH), Bethesda, Maryland, United States of America

Carsten Krebs

Affiliation Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, United States of America

Dana Macelis

Affiliation New England Biolabs, Ipswich, Massachusetts, United States of America

Ramana Madupu

Affiliation J. Craig Venter Institute, Rockville, Maryland, United States of America

Maria J. Martin

Affiliation European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, United Kingdom

Jeffrey H. Miller

Affiliation Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, California, United States of America

Claire O'Donovan

Affiliation European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, United Kingdom

Bernhard Palsson

Affiliation Department of Bioengineering, University of California, San Diego, La Jolla, California, United States of America

Patrick Ruch

Affiliations Department of Library and Information Sciences, University of Applied Sciences Western Switzerland, Geneva, Switzerland, Bibliomics and Text Mining Group, Swiss Institute of Bioinformatics, Geneva, Switzerland

Aaron Setterdahl

Affiliation Department of Chemistry, Indiana University Southeast, New Albany, Indiana, United States of America

Granger Sutton

Affiliation J. Craig Venter Institute, Rockville, Maryland, United States of America

John Tate

Affiliation Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, United Kingdom

Alexander Yakunin

Affiliation Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada

Dmitri Tchigvintsev

Affiliation Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada

Germán Plata

Affiliations Center for Computational Biology and Bioinformatics, Columbia University, New York, New York, United States of America, Integrated Program in Cellular, Molecular, Structural, and Genetic Studies, Columbia University, New York, New York, United States of America

Jie Hu

Affiliation Center for Computational Biology and Bioinformatics, Columbia University, New York, New York, United States of America

Russell Greiner

Affiliation Department of Computing Science, University of Alberta, Edmonton, Alberta, Canada

David Horn

Affiliation School of Physics and Astronomy, Tel Aviv University, Tel Aviv, Israel

Kimmen Sjölander

Affiliation Berkeley Phylogenomics Group, University of California, Berkeley, California, United States of America

Steven L. Salzberg

Affiliation Departments of Medicine and Biostatistics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Dennis Vitkup

Affiliation Center for Computational Biology and Bioinformatics, Columbia University, New York, New York, United States of America

Stanley Letovsky

Affiliation Bioinformatics Program, Boston University, Boston, Massachusetts, United States of America

Daniel Segrè

Affiliation Bioinformatics Program, Boston University, Boston, Massachusetts, United States of America

Charles DeLisi

Affiliation Bioinformatics Program, Boston University, Boston, Massachusetts, United States of America

Richard J. Roberts

Affiliations New England Biolabs, Ipswich, Massachusetts, United States of America, Bioinformatics Program, Boston University, Boston, Massachusetts, United States of America

Martin Steffen

Affiliation Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America

Simon Kasif

anton@neb.com (BPA); kasif@bu.edu (SK)

Affiliations Bioinformatics Program, Boston University, Boston, Massachusetts, United States of America, Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.