About the Authors

Christopher A. Maxwell, Laia Gómez-Baldó, Núria Bonifaci, Helena Aguilar, Alberto Villanueva, Alvaro Aytes, Jordi Serra-Musach, Gemma Aiza, Griselda Martrat, Ander Urruticoechea, Miguel Angel Pujana
Translational Research Laboratory, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Catalonia, Spain

Javier Benítez, Ana Osorio, Ricardo Fernández-Ramires
Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, Spain

Javier Benítez, Ana Osorio, Ricardo Fernández-Ramires
Biomedical Research Centre Network for Rare Diseases, Spain

Laia Gómez-Baldó, Núria Bonifaci, Elisabet Guinó, Víctor Moreno, Miguel Angel Pujana
Biomedical Research Centre Network for Epidemiology and Public Health, Spain

Núria Bonifaci, Elisabet Guinó, Jordi Serra-Musach, Víctor Moreno, Miguel Angel Pujana
Biomarkers and Susceptibility Unit, Catalan Institute of Oncology, IDIBELL, L'Hospitalet, Catalonia, Spain

Sylvain V. Costes, Mary Helen Barcellos-Hoff
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

Helen Chen, Gareth J. R. Evans, Pooja Mohan
Child and Family Research Institute, Vancouver, British Columbia, Canada

Isabel Català, Anna Petit
Department of Pathology, University Hospital of Bellvitge, IDIBELL, L'Hospitalet, Catalonia, Spain

Gad Rennert, Flavio Lejbkowicz
CHS National Cancer Control Center, Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, Technion, Haifa, Israel

Paolo Peterlongo, Carla B. Ripamonti, Paolo Radice
Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori, and IFOM Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy

Siranoush Manoukian, Bernard Peissel, Carla B. Ripamonti
Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

Bernardo Bonanni
Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, Italy

Alessandra Viel
Division of Experimental Oncology 1, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy

Anna Allavena
Department of Genetics, Biology and Biochemistry, University of Turin, Turin, Italy

Loris Bernard
Department of Experimental Oncology, Istituto Europeo di Oncologia, and Consortium for Genomics Technology (Cogentech), Milan, Italy

Eitan Friedman, Bella Kaufman, Yael Laitman, Maya Dubrovsky, Roni Milgrom
The Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Chaim Sheba Medical Center, Ramat Gan, Israel

Eitan Friedman
Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel

Anna Jakubowska, Cezary Cybulski, Bohdan Gorski, Katarzyna Jaworska, Katarzyna Durda, Grzegorz Sukiennicki, Jan Lubiński
International Hereditary Cancer Centre, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland

Yin Yao Shugart
Unit of Statistical Genetics, Division of Intramural Research Program, National Institute of Mental Health, National Institute of Health, Bethesda, Maryland, United States of America

Susan M. Domchek, Richard Letrero, Barbara L. Weber, Katherine L. Nathanson
Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Frans B. L. Hogervorst
Family Cancer Clinic, Department of Pathology, The Netherlands Cancer Institute, Amsterdam, the Netherlands

Matti A. Rookus
Department of Epidemiology, The Netherlands Cancer Institute, Amsterdam, the Netherlands

J. Margriet Collee
Department of Clinical Genetics, Rotterdam Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, the Netherlands

Peter Devilee
Department of Genetic Epidemiology, Leiden University Medical Center, Leiden, the Netherlands

Marjolijn J. Ligtenberg
Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands

Rob B. van der Luijt
Department of Clinical Molecular Genetics, Utrecht University Medical Center, Utrecht, the Netherlands

Cora M. Aalfs
Department of Clinical Genetics, Academic Medical Center, Amsterdam, the Netherlands

Quinten Waisfisz
Department of Clinical Genetics, VU University Medical Center, Amsterdam, the Netherlands

Juul Wijnen
Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands

Cornelis E. P. van Roozendaal
Department of Clinical Genetics, University Medical Center, Maastricht, the Netherlands

HEBON
Hereditary Breast and Ovarian Cancer Group, the Netherlands

EMBRACE, Douglas F. Easton, Susan Peock, Margaret Cook, Clare Oliver, Debra Frost, Lesley McGuffog, Antonis C. Antoniou
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

Patricia Harrington
Department of Oncology, University of Cambridge, Cambridge, United Kingdom

D. Gareth Evans, Fiona Lalloo
Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom

Rosalind Eeles
The Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Surrey, United Kingdom

Louise Izatt
Clinical Genetics, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom

Carol Chu
Yorkshire Regional Genetics Service, St. James's Hospital, Leeds, United Kingdom

Diana Eccles
Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton, United Kingdom

Fiona Douglas
Institute of Human Genetics, Centre for Life, Newcastle Upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, United Kingdom

Carole Brewer
Department of Clinical Genetics, Royal Devon & Exeter Hospital, Exeter, United Kingdom

Heli Nevanlinna, Tuomas Heikkinen
Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland

Fergus J. Couch, Xianshu Wang
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America

Noralane M. Lindor
Department of Medical Genetics, Mayo Clinic, Rochester, Minnesota, United States of America

Andrew K. Godwin
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, United States of America

Maria A. Caligo, Grazia Lombardi
Section of Genetic Oncology, Department of Oncology, University of Pisa, and Department of Laboratory Medicine, University Hospital of Pisa, Pisa, Italy

Niklas Loman
Department of Oncology, Lund University Hospital, Lund, Sweden

Per Karlsson
Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden

Hans Ehrencrona
Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden

Anna von Wachenfeldt
Department of Oncology, Karolinska University Hospital, Stockholm, Sweden

SWE-BRCA
Swedish Breast Cancer Study, Sweden

Rosa Bjork Barkardottir
Department of Pathology, Landspitali-University Hospital, Reykjavik, Iceland

Ute Hamann
Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum, Heidelberg, Germany

Muhammad U. Rashid
Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum, Heidelberg, Germany, and Department of Basic Sciences, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan

Adriana Lasa
Genetic Service, Hospital de la Santa Creu i Sant Pau, Barcelona, Catalonia, Spain

Trinidad Caldés
Molecular Oncology Laboratory, Hospital Clínico San Carlos, Madrid, Spain

Raquel Andrés
Medical Oncology Division, Hospital Clínico de Zaragoza, Zaragoza, Spain

Michael Schmitt
Department of Internal Medicine III, University of Rostock, Rostock, Germany

Volker Assmann
Center for Experimental Medicine, Institute of Tumor Biology, University Hospital Hamburg–Eppendorf, Hamburg, Germany

Kristen Stevens
Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, United States of America

Kenneth Offit
Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

João Curado, Hagen Tilgner, Roderic Guigó
Bioinformatics and Genomics Group, Centre for Genomic Regulation (CRG), Biomedical Research Park of Barcelona (PRBB), Barcelona, Catalonia, Spain

Joan Brunet, Joan Castellsagué, Ignacio Blanco, Conxi Lázaro, Gabriel Capellá
Genetic Counseling and Hereditary Cancer Programme, Catalan Institute of Oncology, IDIBELL and Girona Biomedical Research Institute (IdIBGi), Catalonia, Spain

Laima Tihomirova
Latvian Biomedical Research and Study Center, Riga, Latvia

David E. Goldgar
Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah, United States of America

Saundra Buys
Department of Internal Medicine, Huntsman Cancer Institute, Salt Lake City, Utah, United States of America

Esther M. John
Cancer Prevention Institute of California, Fremont, California, United States of America

Alexander Miron
Department of Cancer Biology, Dana-Farber Cancer Institute, and Department of Surgery, Harvard Medical School, Boston, Massachusetts, United States of America

Melissa Southey
Centre for Molecular, Environmental, Genetic and Analytic (MEGA) Epidemiology, Melbourne School of Population Health, The University of Melbourne, Victoria, Australia

Mary B. Daly
Division of Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America

BCFR
Breast Cancer Family Registry, United States of America

Rita K. Schmutzler, Barbara Wappenschmidt
Center for Familial Breast and Ovarian Cancer and Center of Integrated Oncology, University of Cologne, Cologne, Germany

Alfons Meindl
Department of Obstetrics and Gynaecology, Klinikum rechts der Isar, Technical University, Munich, Germany

Norbert Arnold
Division of Oncology, Department of Gynaecology and Obstetrics, University Hospital Schleswig-Holstein, Kiel, Germany

Helmut Deissler
Department of Obstetrics and Gynecology, Ulm University, Ulm, Germany

Raymonda Varon-Mateeva
Institut für Humangenetik, Charité-Universitätsmedizin Berlin, Berlin, Germany

Christian Sutter
Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany

Dieter Niederacher
Division of Molecular Genetics, Department of Gynaecology and Obstetrics, Clinical Center University of Düsseldorf, Düsseldorf, Germany

Evgeny Imyamitov
N. N. Petrov Institute of Oncology, Saint-Petersburg, Russian Federation

Olga M. Sinilnikova
Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Centre Hospitalier Universitaire de Lyon, Centre Léon Bérard, Lyon, France

Olga M. Sinilnikova, Sylvie Mazoyer, Carole Verny-Pierre
Equipe labellisée LIGUE 2008, UMR5201 CNRS, Centre Léon Bérard, Université de Lyon, Lyon, France

Dominique Stoppa-Lyonne, Laurent Castera, Antoine de Pauw
INSERM U509, Service de Génétique Oncologique, Institut Curie, Université Paris-Descartes, Paris, France

Yves-Jean Bignon, Nancy Uhrhammer
Département d'Oncogénétique, Centre Jean Perrin, Université de Clermont-Ferrand, Clermont-Ferrand, France

Jean-Philippe Peyrat
Laboratoire d'Oncologie Moléculaire Humaine, Centre Oscar Lambret, Lille, France

Philippe Vennin
Consultation d'Oncogénétique, Centre Oscar Lambret, Lille, France

Sandra Fert Ferrer
Laboratoire de Génétique Chromosomique, Hôtel Dieu Centre Hospitalier, Chambéry, France

Marie-Agnès Collonge-Rame
Service de Génétique-Histologie-Biologie du Développement et de la Reproduction, Centre Hospitalier Universitaire de Besançon, Besançon, France

Isabelle Mortemousque
Service de Génétique, Centre Hospitalier Universitaire Bretonneau, Tours, France

GEMO Study Collaborators
GEMO Study (Genetics Network “Groupe Génétique et Cancer”), Fédération Nationale des Centres de Lutte Contre le Cancer, France

Amanda B. Spurdle, Jonathan Beesley, Xiaoqing Chen, Sue Healey, Georgia Chenevix-Trench
Queensland Institute of Medical Research, Brisbane, Australia

kConFab
The Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer, Peter MacCallum Cancer Institute, East Melbourne, Australia

Marc Vidal
Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana-Farber Cancer Institute, and Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

Stephen B. Gruber
Department of Internal Medicine, Epidemiology, Human Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

Markus C. Fleisch
Department of Obstetrics and Gynaecologie, Heinrich-Heine-University, Duesseldorf, Germany

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: CAM J Benitez MAP. Performed the experiments: CAM LG-B AO RF-R SVC HC GJRE PM HA A Villanueva A Aytes GA J Castellsagué DN MCF MAP. Analyzed the data: NB EG IC AP JS-M GR FLejbkowicz RL WLB JCurado HT RG SBG CL LM KLN ACA VM MAP. Contributed reagents/materials/analysis tools: CAM JBenitez AO GR FLejbkowicz PP S Manoukian BP CBR BB A Viel AAllavena LB PR EF BK YL MD RM AJ CCybulski BG KJ KD GS JL YYS SMD RL BLW FBLH MAR JMC PD MJL RBvdL CMA QW JW CEPvR HEBON EMBRACE DFE SP MC CO DF PH DGE FLalloo RE LI CChu DE FD CB HN TH FJC NML XW AKG MAC GL NL PK HE AvW SWE-BRCA RBB UH MUR AL TC RA MS VA KS KO JBrunet GM AU IB LT DEG SB EMJ AM MS MBD BCFR RKS BW AM NA HD RV-M CS DN EI OMS DS-L SMazoyer CV-P LC AdP Y-JB NU J-PP PV SFF M-AC-R IM GEMO ABS JBeesley XC SH kConFab MHB-H MV CL GC LM KLN ACA GC-T MCF VM MAP. Wrote the paper: CAM MAP.