About the Authors

Barbara Celona

Affiliation San Raffaele University, Milan, Italy

Assaf Weiner

Affiliations School of Computer Science and Engineering, Hebrew University, Jerusalem, Israel, Alexander Silberman Institute of Life Sciences, Hebrew University, Jerusalem, Israel

Francesca Di Felice

Affiliation Dipartimento di Biologia e Biotecnologie, Università di Roma La Sapienza, Rome, Italy

Francesco M. Mancuso

Address Current address: Bioinformatics Unit, Centre for Genomic Regulation (CRG) and UPF, Barcelona, Spain

Affiliation IFOM-IEO Campus, Milan, Italy

Elisa Cesarini

Affiliation Dipartimento di Biologia e Biotecnologie, Università di Roma La Sapienza, Rome, Italy

Riccardo L. Rossi

Affiliation Integrative Biology Program, Istituto Nazionale di Genetica Molecolare, Milan, Italy

Lorna Gregory

Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

Dilair Baban

Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

Grazisa Rossetti

Affiliation Integrative Biology Program, Istituto Nazionale di Genetica Molecolare, Milan, Italy

Paolo Grianti

Affiliation Dipartimento di Scienze Biomolecolari e Biotecnologie, Università degli Studi di Milano, Milan, Italy

Massimiliano Pagani

Affiliation Integrative Biology Program, Istituto Nazionale di Genetica Molecolare, Milan, Italy

Tiziana Bonaldi

Affiliation IFOM-IEO Campus, Milan, Italy

Jiannis Ragoussis

Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

Nir Friedman

Affiliations School of Computer Science and Engineering, Hebrew University, Jerusalem, Israel, Alexander Silberman Institute of Life Sciences, Hebrew University, Jerusalem, Israel

Giorgio Camilloni

Affiliations Dipartimento di Biologia e Biotecnologie, Università di Roma La Sapienza, Rome, Italy, Istituto di Biologia e Patologia Molecolari, CNR, Rome, Italy

Marco E. Bianchi

bianchi.marco@hsr.it (MEB); agresti.alessandra@hsr.it (AA)

Affiliations San Raffaele University, Milan, Italy, Division of Genetics and Cell Biology, San Raffaele Research Institute, Milan, Italy

Alessandra Agresti

bianchi.marco@hsr.it (MEB); agresti.alessandra@hsr.it (AA)

Affiliation Division of Genetics and Cell Biology, San Raffaele Research Institute, Milan, Italy

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: BC AW NF MEB AA. Performed the experiments: BC FDF EC PG GR. Analyzed the data: BC AW FMM RLR LG DB MP TB. Contributed reagents/materials/analysis tools: AW MP TB JR GC NF MEB AA. Wrote the paper: BC AW NF MEB AA. BC performed experiments on mammalian cells and mice; AW bioinformatic analyses for nucleosome positioning and modeling; FDF, EC, PG, and BC experiments on yeast; BC and FMM bioinformatics for proteome analysis; BC, RLR, GR, and MP transcriptome analyses of mammalian cells; and LG and DB high-throughput sequencing and transcriptome analyses of yeast cells. BC, MEB, and AA formulated the hypotheses. BC, MP, TB, JR, NF, GC, MEB, and AA analyzed the results (mammalian transcriptomics, MP; proteomics, TB; high throughput sequencing and transcriptome analyses of yeast cells, JR; bioinformatic analyses for nucleosome positioning and modeling, NF; experiments on yeast, GC; experiments on mammalian cells and mice, BC, MEB, and AA). MEB and AA coordinated the whole work.