About the Authors

Shulin Ju

Affiliations Department of Biochemistry and Chemistry, Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, Massachusetts, United States of America, Department of Neurology and Center for Neurologic Diseases, Harvard Medical School and Brigham & Women's Hospital, Cambridge, Massachusetts, United States of America

Daniel F. Tardiff

Affiliations Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America, Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Haesun Han

Affiliations Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America, Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Kanneganti Divya

Affiliation Department of Biochemistry and Chemistry, Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, Massachusetts, United States of America

Quan Zhong

Affiliations Department of Cancer Biology, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

Lynne E. Maquat

Affiliation Department of Biochemistry and Biophysics and Center for RNA Biology, School of Medicine and Dentistry, University of Rochester, Rochester, New York, United States of America

Daryl A. Bosco

Affiliation Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Lawrence J. Hayward

Affiliation Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Robert H. Brown Jr.

Affiliation Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Susan Lindquist

Affiliations Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America, Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Dagmar Ringe

ringe@brandeis.edu (DR); petsko@brandeis.edu (GAP)

Affiliations Department of Biochemistry and Chemistry, Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, Massachusetts, United States of America, Department of Neurology and Center for Neurologic Diseases, Harvard Medical School and Brigham & Women's Hospital, Cambridge, Massachusetts, United States of America

Gregory A. Petsko

ringe@brandeis.edu (DR); petsko@brandeis.edu (GAP)

Affiliations Department of Biochemistry and Chemistry, Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, Massachusetts, United States of America, Department of Neurology and Center for Neurologic Diseases, Harvard Medical School and Brigham & Women's Hospital, Cambridge, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: SJ DFT LEM DAB LJH RHB SL DR GAP. Performed the experiments: SJ DFT HH KD QZ. Analyzed the data: SJ DFT HH KD QZ LEM DAB LJH RHB SL DR GAP. Contributed reagents/materials/analysis tools: SJ DFT HH KD QZ LEM DAB LJH RHB SL. Wrote the paper: SJ DFT HH KD QZ LEM DAB LJH RHB SL DR GAP.