About the Authors
- Xiaokun Shu
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* E-mail: rtsien@ucsd.edu (RYT); xiaokun.shu@ucsf.edu (XS)
Current address: Department of Pharmaceutical Chemistry and Cardiovascular Research Institute, University of California at San Francisco, San Francisco, California, United States of America
Affiliations Howard Hughes Medical Institute, University of California at San Diego, La Jolla, California, United States of America, Department of Pharmacology, University of California at San Diego, La Jolla, California, United States of America
- Varda Lev-Ram
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Affiliation Department of Pharmacology, University of California at San Diego, La Jolla, California, United States of America
- Thomas J. Deerinck
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Affiliation National Center for Microscopy and Imaging Research, Center for Research on Biological Systems, University of California at San Diego, La Jolla, California, United States of America
- Yingchuan Qi
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Affiliations Howard Hughes Medical Institute, University of California at San Diego, La Jolla, California, United States of America, Division of Biological Science, Section of Neurobiology, University of California at San Diego, La Jolla, California, United States of America
- Ericka B. Ramko
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Affiliation National High Magnetic Field Laboratory and Department of Biological Science, The Florida State University, Tallahassee, Florida, United States of America
- Michael W. Davidson
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Affiliation National High Magnetic Field Laboratory and Department of Biological Science, The Florida State University, Tallahassee, Florida, United States of America
- Yishi Jin
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Affiliations Howard Hughes Medical Institute, University of California at San Diego, La Jolla, California, United States of America, Division of Biological Science, Section of Neurobiology, University of California at San Diego, La Jolla, California, United States of America
- Mark H. Ellisman
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Affiliations National Center for Microscopy and Imaging Research, Center for Research on Biological Systems, University of California at San Diego, La Jolla, California, United States of America, Department of Neurosciences, University of California at San Diego, La Jolla, California, United States of America,
- Roger Y. Tsien
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* E-mail: rtsien@ucsd.edu (RYT); xiaokun.shu@ucsf.edu (XS)
Affiliations Howard Hughes Medical Institute, University of California at San Diego, La Jolla, California, United States of America, Department of Pharmacology, University of California at San Diego, La Jolla, California, United States of America, Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, California, United States of America
Competing Interests
The authors have declared that no competing interests exist.
Author Contributions
The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: XS RYT. Performed the experiments: XS VL TJD YQ EBR MWD. Analyzed the data: XS VL TJD YQ MWD YJ MHE RYT. Contributed reagents/materials/analysis tools: XS VL TJD YQ EBR MWD YJ MHE RYT. Wrote the paper: XS MHE RYT. Proposal of engineering FMN-binding phototropins as genetically encoded and efficient SOGs, with following research design, engineering, and characterization of miniSOG: XS. Coordination and guidance of correlated LM/EM: MHE. Coordination and proposal of the desirability of a genetically encoded SOG: RYT.