About the Authors

Carmelo Ferrai

Contributed equally to this work with: Carmelo Ferrai, Sheila Q. Xie

Affiliations Laboratory of Molecular Dynamics of the Nucleus, Division of Genetics and Cell Biology, S. Raffaele Scientific Institute, Milan, Italy, Medical Research Council Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital Campus, London, United Kingdom

Sheila Q. Xie

Contributed equally to this work with: Carmelo Ferrai, Sheila Q. Xie

Affiliation Medical Research Council Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital Campus, London, United Kingdom

Paolo Luraghi

Current address: Institute for Cancer Research and Treatment (IRCC), Torino, Italy

Affiliation Laboratory of Molecular Dynamics of the Nucleus, Division of Genetics and Cell Biology, S. Raffaele Scientific Institute, Milan, Italy

Davide Munari

Current address: FIRC Institute of Molecular Oncology (IFOM), Milan, Italy

Affiliation Laboratory of Molecular Dynamics of the Nucleus, Division of Genetics and Cell Biology, S. Raffaele Scientific Institute, Milan, Italy

Francisco Ramirez

Affiliation South Ruislip, Middlesex, United Kingdom

Miguel R. Branco

Current address: The Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom

Affiliation Medical Research Council Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital Campus, London, United Kingdom

Ana Pombo

ana.pombo@csc.mrc.ac.uk (AP); crippa.massimo@hsr.it (MPC)

Affiliation Medical Research Council Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital Campus, London, United Kingdom

Massimo P. Crippa

ana.pombo@csc.mrc.ac.uk (AP); crippa.massimo@hsr.it (MPC)

Affiliation Laboratory of Molecular Dynamics of the Nucleus, Division of Genetics and Cell Biology, S. Raffaele Scientific Institute, Milan, Italy

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: CF AP MPC. Performed the experiments: CF SQX PL DM. Analyzed the data: CF SQX FR AP MPC. Contributed reagents/materials/analysis tools: CF SQX MRB AP. Wrote the paper: CF SQX AP MPC. Performed the experiments on uPA expression (mRNA and protein), MN digestion of chromatin, MN-ChIP: CF PL. Performed immuno-cryoFISH experiments and analyses: SQX. Performed statistical analysis: FR AP.