About the Authors

Fekrije Selimi

Affiliations Laboratory of Molecular Biology, Howard Hughes Medical Institute, The Rockefeller University, New York, New York, United States of America , CNRS, UMR7102, Paris, France , UPMC, UMR7102, Paris, France

Ileana M Cristea

Affiliations Laboratory for Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, New York, New York, United States of America , Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America

Elizabeth Heller

Affiliation Laboratory of Molecular Biology, Howard Hughes Medical Institute, The Rockefeller University, New York, New York, United States of America

Brian T Chait

Affiliation Laboratory for Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, New York, New York, United States of America

Nathaniel Heintz

To whom correspondence should be addressed. E-mail: heintz@mail.rockefeller.edu

Affiliation Laboratory of Molecular Biology, Howard Hughes Medical Institute, The Rockefeller University, New York, New York, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

FS generated the transgenic mice and performed immunofluorescence studies and functional analysis of MRCK╬│. FS and EH performed the biochemical purifications of postsynaptic densities and their western blot analysis. IMC optimized the bead conjugation protocol and performed MS analysis. FS and NH prepared the manuscript. FS, IMC, EH, BTC, and NH discussed the experiments, the data, and the manuscript.