About the Authors

Cedric Montanier

Contributed equally to this work with: Cedric Montanier, Victoria A Money

Affiliation Institute for Cell and Molecular Biosciences, Newcastle University, The Medical School, Newcastle upon Tyne, United Kingdom

Victoria A Money

Contributed equally to this work with: Cedric Montanier, Victoria A Money

Affiliation York Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York, United Kingdom

Virginia M. R Pires

Affiliation CIISA - Faculdade de Medicina Veterinária, Universidade Técnica de Lisboa, Avenida da Universidade Técnica, Lisboa, Portugal

James E Flint

Affiliation Institute for Cell and Molecular Biosciences, Newcastle University, The Medical School, Newcastle upon Tyne, United Kingdom

Benedita A Pinheiro

Affiliation CIISA - Faculdade de Medicina Veterinária, Universidade Técnica de Lisboa, Avenida da Universidade Técnica, Lisboa, Portugal

Arun Goyal

Affiliation CIISA - Faculdade de Medicina Veterinária, Universidade Técnica de Lisboa, Avenida da Universidade Técnica, Lisboa, Portugal

José A. M Prates

Affiliation CIISA - Faculdade de Medicina Veterinária, Universidade Técnica de Lisboa, Avenida da Universidade Técnica, Lisboa, Portugal

Atsushi Izumi

Affiliation York Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York, United Kingdom

Henrik Stålbrand

Affiliation Department of Biochemistry, Center for Chemistry and Chemical Engineering, Lund University, Lund, Sweden

Carl Morland

Affiliation Institute for Cell and Molecular Biosciences, Newcastle University, The Medical School, Newcastle upon Tyne, United Kingdom

Alan Cartmell

Affiliation Institute for Cell and Molecular Biosciences, Newcastle University, The Medical School, Newcastle upon Tyne, United Kingdom

Katarina Kolenova

Affiliation Department of Biochemistry, Center for Chemistry and Chemical Engineering, Lund University, Lund, Sweden

Evangelos Topakas

Affiliation Institute for Cell and Molecular Biosciences, Newcastle University, The Medical School, Newcastle upon Tyne, United Kingdom

Eleanor J Dodson

Affiliation York Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York, United Kingdom

David N Bolam

Affiliation Institute for Cell and Molecular Biosciences, Newcastle University, The Medical School, Newcastle upon Tyne, United Kingdom

Gideon J Davies

To whom correspondence should be addressed. E-mail: davies@ysbl.york.ac.uk (GJD); H.J.Gilbert@ncl.ac.uk (HJG)

Affiliation York Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York, United Kingdom

Carlos M. G. A Fontes

Affiliation CIISA - Faculdade de Medicina Veterinária, Universidade Técnica de Lisboa, Avenida da Universidade Técnica, Lisboa, Portugal

Harry J Gilbert

To whom correspondence should be addressed. E-mail: davies@ysbl.york.ac.uk (GJD); H.J.Gilbert@ncl.ac.uk (HJG)

Affiliation Institute for Cell and Molecular Biosciences, Newcastle University, The Medical School, Newcastle upon Tyne, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

CM, JEF, HS, AC, ET, DNB, GJD, CMGAF, and HJG conceived and designed the experiments. CM, VAM, VMRP, JEF, BAP, AG, JAMP, AI, HS, CM, AC, ET, DNB, GJD, and CMGAF performed the experiments. CM, VAM, VMRP, JEF, BAP, AG, JAMP, AI, HS, CM, AC, KK, ET, EJD, DNB, GJD, CMGAF, and HJG analyzed the data. KK contributed reagents/materials/analysis tools. DNB, GJD, and HJG wrote the paper.