About the Authors

Michael J Barnes

To whom correspondence should be addressed. E-mail: mbarnes@scripps.edu (MJB); Kasper.Hoebe@cchmc.org (KH)

Affiliation Department of Genetics, The Scripps Research Institute, La Jolla, California, United States of America

Philippe Krebs

Affiliation Department of Genetics, The Scripps Research Institute, La Jolla, California, United States of America

Nathaniel Harris

Affiliation Division of Molecular Immunology, Cincinnati Children's Hospital Research Foundation, Cincinnati, Ohio, United States of America

Celine Eidenschenk

Affiliation Department of Genetics, The Scripps Research Institute, La Jolla, California, United States of America

Rosana Gonzalez-Quintial

Affiliation Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America

Carrie N Arnold

Affiliation Department of Genetics, The Scripps Research Institute, La Jolla, California, United States of America

Karine Crozat

Affiliation Department of Genetics, The Scripps Research Institute, La Jolla, California, United States of America

Sosathya Sovath

Affiliation Department of Genetics, The Scripps Research Institute, La Jolla, California, United States of America

Eva Marie Moresco

Affiliation Department of Genetics, The Scripps Research Institute, La Jolla, California, United States of America

Argyrios N Theofilopoulos

Affiliation Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America

Bruce Beutler

Affiliation Department of Genetics, The Scripps Research Institute, La Jolla, California, United States of America

Kasper Hoebe

To whom correspondence should be addressed. E-mail: mbarnes@scripps.edu (MJB); Kasper.Hoebe@cchmc.org (KH)

Affiliation Division of Molecular Immunology, Cincinnati Children's Hospital Research Foundation, Cincinnati, Ohio, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

MJB and KH conceived and designed the experiments. MJB, PK, NH, CE, RGQ, CNA, and KC performed the experiments. MJB, SS, EMM, ANT, BB, and KH analyzed the data. KC, ANT, and BB contributed reagents/materials/analysis tools. MJB wrote the paper.