About the Authors

David Ng

Contributed equally to this work with: David Ng, Graham M Pitcher

Affiliations Program in Developmental Biology, The Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada , Program in Genetics & Genome Biology, The Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada , Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada , Neurosciences & Mental Health, The Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada

Graham M Pitcher

Contributed equally to this work with: David Ng, Graham M Pitcher

Affiliations Neurosciences & Mental Health, The Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada , Department of Physiology, University of Toronto, Toronto, Ontario, Canada

Rachel K Szilard

Affiliations Program in Developmental Biology, The Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada , Program in Genetics & Genome Biology, The Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada

Andréa Sertié

Affiliations Program in Developmental Biology, The Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada , Program in Genetics & Genome Biology, The Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada

Marijana Kanisek

Affiliations Department of Physiology, University of Toronto, Toronto, Ontario, Canada , Mount Sinai Hospital Research Institute, Toronto, Ontario, Canada

Steven J Clapcote

Affiliation Mount Sinai Hospital Research Institute, Toronto, Ontario, Canada

Tatiana Lipina

Affiliation Mount Sinai Hospital Research Institute, Toronto, Ontario, Canada

Lorraine V Kalia

Affiliations Neurosciences & Mental Health, The Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada , Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada

Daisy Joo

Affiliation Neurosciences & Mental Health, The Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada

Colin McKerlie

Affiliation Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada

Miguel Cortez

Affiliation Neurosciences & Mental Health, The Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada

John C Roder

Affiliations Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada , Mount Sinai Hospital Research Institute, Toronto, Ontario, Canada

Michael W Salter

To whom correspondence should be addressed. E-mail: mike.salter@utoronto.ca (MWS); mcinnes@sickkids.ca (RRM)

Affiliations Neurosciences & Mental Health, The Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada , Department of Physiology, University of Toronto, Toronto, Ontario, Canada , Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada

Roderick R McInnes

To whom correspondence should be addressed. E-mail: mike.salter@utoronto.ca (MWS); mcinnes@sickkids.ca (RRM)

Affiliations Program in Developmental Biology, The Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada , Program in Genetics & Genome Biology, The Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada , Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada , Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada , Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

DN, GMP, RKS, AS, MK, SJC, TL, JCR, MWS, and RRM conceived and designed the experiments. DN, GMP, RKS, AS, MK, SJC, TL, DJ, and MC performed the experiments. DN, GMP, RKS, AS, MK, SJC, TL, DJ, CM, MC, MWS, and RRM analyzed the data. LVK contributed reagents/materials/analysis tools. DN, GMP, MWS, and RRM wrote the paper.