About the Authors

Morris E Feldman

Affiliation Howard Hughes Medical Institute and Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, United States of America

Beth Apsel

Affiliation Howard Hughes Medical Institute and Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, United States of America

Aino Uotila

Affiliation Department of Molecular Biology, University of Geneva, Switzerland

Robbie Loewith

Affiliation Department of Molecular Biology, University of Geneva, Switzerland

Zachary A Knight

Address ¤ Current address: The Rockefeller University, New York, New York, United States of America

Affiliation Howard Hughes Medical Institute and Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, United States of America

Davide Ruggero

Affiliation School of Medicine and Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, United States of America

Kevan M Shokat

To whom correspondence should be addressed. E-mail: shokat@cmp.ucsf.edu

Affiliation Howard Hughes Medical Institute and Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, United States of America

Competing Interests

MEF, BA, ZAK, and KMS are inventors on patent applications owned by UCSF related to PP242 and licensed to Intellikine. ZAK and KMS are consultants to Intellikine.

Author Contributions

MEF, AU, RL, ZAK, DR, and KMS conceived and designed the experiments. MEF, BA, and AU performed the experiments. MEF, BA, AU, and KMS analyzed the data. BA, RL, ZAK, DR, and KMS contributed reagents/materials/analysis tools. MEF, BA, ZAK, DR, and KMS wrote the paper.