About the Authors

Jean-Philippe Coppé

Affiliation Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

Christopher K Patil

Contributed equally to this work with: Christopher K Patil, Francis Rodier

Affiliation Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

Francis Rodier

Contributed equally to this work with: Christopher K Patil, Francis Rodier

Affiliations Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America , Buck Institute for Age Research, Novato, California, United States of America

Yu Sun

Affiliation Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

Denise P Muñoz

Affiliations Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America , Buck Institute for Age Research, Novato, California, United States of America

Joshua Goldstein

Address ¤ Current address: Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America

Affiliation Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

Peter S Nelson

Affiliation Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

Pierre-Yves Desprez

Affiliations Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America , California Pacific Medical Center Research Institute, San Francisco, California, United States of America

Judith Campisi

To whom correspondence should be addressed. E-mail: jcampisi@lbl.gov

Affiliations Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America , Buck Institute for Age Research, Novato, California, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

JPC and CKP carried out and analyzed array experiments. JPC and FR conceived and designed genetic experiments. JPC, JG, and PYD designed and carried out the biological activity experiments. JPC, YS, and PSN designed and carried out the clinical experiments, JPC, DPM and JG designed and carried out the immunofluorescence experiments, JPC analyzed the data, JPC, CKP, FR, PYD, and JC wrote the paper.