Evolution Acts on Enhancer Organization to Fine-Tune Gradient Threshold Readouts

Justin Crocker; Yoichiro Tamori; Albert Erives

doi:10.1371/journal.pbio.0060263

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Open Access

Peer-reviewed

Research Article

Evolution Acts on Enhancer Organization to Fine-Tune Gradient Threshold Readouts

Justin Crocker,

Affiliation Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire, United States of America
⨯
Yoichiro Tamori,

¤ Current address: Department of Biological Sciences, Florida State University, Tallahassee, Florida, United States of America

Affiliation Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire, United States of America
⨯
Albert Erives

*To whom correspondence should be addressed. E-mail: albert.erives@dartmouth.edu

Affiliation Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire, United States of America
⨯

Evolution Acts on Enhancer Organization to Fine-Tune Gradient Threshold Readouts

Justin Crocker,
Yoichiro Tamori,
Albert Erives

Published: November 4, 2008
https://doi.org/10.1371/journal.pbio.0060263

About the Authors

Justin Crocker

Affiliation Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire, United States of America

Yoichiro Tamori

¤ Current address: Department of Biological Sciences, Florida State University, Tallahassee, Florida, United States of America

Affiliation Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire, United States of America

Albert Erives

*To whom correspondence should be addressed. E-mail: albert.erives@dartmouth.edu

Affiliation Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

AE conceived and directed the work. JC conducted the whole-genome bioinformatic analyses, constructed all of the transgenic animals, and performed in situ hybridization assays. AE and JC analyzed all the data. YT assisted with characterization of the sog locus. AE wrote the paper. All authors commented on the manuscript.

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Drosophila melanogaster
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Invertebrate genomics
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Sequence motif analysis
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Evolutionary developmental biology
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Genetic loci
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Embryos
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Morphogens
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Evolutionary adaptation
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