About the Authors

Ji Li

Affiliation Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America

Atsushi Ebata

Affiliation Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America

Yuqing Dong

Address ¤ Current address: Department of Biological Sciences, Clemson University, Clemson, South Carolina, United States of America

Affiliation Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America

Gizem Rizki

Affiliation Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America

Terri Iwata

Affiliation Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America

Siu Sylvia Lee

To whom correspondence should be addressed. E-mail: SSL29@cornell.edu

Affiliation Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

JL, AE, YD, GR, TI, and SSL conceived and performed the experiments and analyzed the data. JL and AE performed the majority of the lifespan analyses with help from YD and TI. JL performed the immunostaining, DAF-16::GFP localization, qRT-PCR, co-IP, and ChIP experiments; AE generated hcf-1::gfp strains, performed the stress assays with help from JL and GR, the dauer and Nile Red assays with help from JL; YD generated the anti-HCF-1 antibody. JL, AE, and SSL wrote the paper.