About the Authors

Chen-Shan Chin

Contributed equally to this work with: Chen-Shan Chin, Victor Chubukov

Affiliation Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, United States of America

Victor Chubukov

Contributed equally to this work with: Chen-Shan Chin, Victor Chubukov

Affiliations Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, United States of America , Joint Graduate Group in Bioengineering, University of California, Berkeley, and University of California, San Francisco, San Francisco, California, United States of America

Emmitt R Jolly

Affiliation Department of Pathology, University of California, San Francisco, San Francisco, California, United States of America

Joe DeRisi

Affiliation Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, United States of America

Hao Li

To whom correspondence should be addressed. E-mail: haoli@genome.ucsf.edu

Affiliations Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, United States of America , Joint Graduate Group in Bioengineering, University of California, Berkeley, and University of California, San Francisco, San Francisco, California, United States of America , Center for Theoretical Biology, Peking University, Beijing, China

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

CC, VC, JD, and HL conceived and design the experiments. CC set up the automated system. CC and VC did the experiments. EJ constructed a number of mutant strains. CC, VC, and HL analyzed data and developed the mathematical model. CC, VC, JD, and HL wrote the manuscript.