About the Authors

Chen-Shan Chin, Victor Chubukov, Joe DeRisi, Hao Li
Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, United States of America

Victor Chubukov, Hao Li
Joint Graduate Group in Bioengineering, University of California, Berkeley, and University of California, San Francisco, San Francisco, California, United States of America

Emmitt R Jolly
Department of Pathology, University of California, San Francisco, San Francisco, California, United States of America

Hao Li
Center for Theoretical Biology, Peking University, Beijing, China

Corresponding Author

haoli@genome.ucsf.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

CC, VC, JD, and HL conceived and design the experiments. CC set up the automated system. CC and VC did the experiments. EJ constructed a number of mutant strains. CC, VC, and HL analyzed data and developed the mathematical model. CC, VC, JD, and HL wrote the manuscript.