About the Authors

Jason L Miller

Address Current address: Promega Corporation, Madison, Wisconsin, United States of America

Affiliation Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America

Johanne Le Coq

Affiliation Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America

Asher Hodes

Affiliations Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California, United States of America , The Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, United States of America

Roman Barbalat

Address Current address: Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, United States of America

Affiliations Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California, United States of America , The Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, United States of America

Jeff F Miller

Affiliations Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California, United States of America , The Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, United States of America

Partho Ghosh

To whom correspondence should be addressed. E-mail: pghosh@ucsd.edu

Affiliations Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America , Section of Molecular Biology, University of California San Diego, La Jolla, California, United States of America

Competing Interests

JFM is a board member of and both JFM and PG have served as consultants for AvidBiotics Corp. and have received compensation for these services. Under an agreement between AvidBiotics Corp. and University of California San Diego, JLM and PG are entitled to inventors' share of licensing revenue received by the University of California San Diego from AvidBiotics Corp.

Author Contributions

PG and JFM conceived and designed the experiments. JLM, JLC, AC, and RB performed the experiments. JLM, JLC, AC, RB, JFM, and PG analyzed the data. PG wrote the paper.