About the Authors

Eric E Schadt

Contributed equally to this work with: Eric E Schadt, Cliona Molony, Eugene Chudin

Affiliation Rosetta Inpharmatics, Seattle, Washington, United States of America

Cliona Molony

Contributed equally to this work with: Eric E Schadt, Cliona Molony, Eugene Chudin

Affiliation Rosetta Inpharmatics, Seattle, Washington, United States of America

Eugene Chudin

Contributed equally to this work with: Eric E Schadt, Cliona Molony, Eugene Chudin

Affiliation Rosetta Inpharmatics, Seattle, Washington, United States of America

Ke Hao

Affiliation Rosetta Inpharmatics, Seattle, Washington, United States of America

Xia Yang

Affiliation Rosetta Inpharmatics, Seattle, Washington, United States of America

Pek Y Lum

Affiliation Rosetta Inpharmatics, Seattle, Washington, United States of America

Andrew Kasarskis

Affiliation Rosetta Inpharmatics, Seattle, Washington, United States of America

Bin Zhang

Affiliation Rosetta Inpharmatics, Seattle, Washington, United States of America

Susanna Wang

Affiliation Rosetta Inpharmatics, Seattle, Washington, United States of America

Christine Suver

Affiliation Rosetta Inpharmatics, Seattle, Washington, United States of America

Jun Zhu

Affiliation Rosetta Inpharmatics, Seattle, Washington, United States of America

Joshua Millstein

Affiliation Rosetta Inpharmatics, Seattle, Washington, United States of America

Solveig Sieberts

Affiliation Rosetta Inpharmatics, Seattle, Washington, United States of America

John Lamb

Affiliation Rosetta Inpharmatics, Seattle, Washington, United States of America

Debraj GuhaThakurta

Affiliation Rosetta Inpharmatics, Seattle, Washington, United States of America

Jonathan Derry

Affiliation Rosetta Inpharmatics, Seattle, Washington, United States of America

John D Storey

Affiliations Rosetta Inpharmatics, Seattle, Washington, United States of America , Department of Biostatistics, University of Washington, Seattle, Washington, United States of America , Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

Iliana Avila-Campillo

Affiliation Rosetta Inpharmatics, Seattle, Washington, United States of America

Mark J Kruger

Affiliation Rosetta Inpharmatics, Seattle, Washington, United States of America

Jason M Johnson

Affiliation Rosetta Inpharmatics, Seattle, Washington, United States of America

Carol A Rohl

Affiliation Rosetta Inpharmatics, Seattle, Washington, United States of America

Atila van Nas

Affiliation Department of Human Genetics, University of California Los Angeles, Los Angeles, California, United States of America

Margarete Mehrabian

Affiliations Department of Microbiology, Molecular Genetics, and Immunology, University of California Los Angeles, Los Angeles, California, United States of America , Department of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

Thomas A Drake

Affiliation Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, California, United States of America

Aldons J Lusis

Affiliations Department of Microbiology, Molecular Genetics, and Immunology, University of California Los Angeles, Los Angeles, California, United States of America , Department of Medicine, University of California Los Angeles, Los Angeles, California, United States of America , Department of Human Genetics, University of California Los Angeles, Los Angeles, California, United States of America

Ryan C Smith

Affiliation Rosetta Inpharmatics, Seattle, Washington, United States of America

F. Peter Guengerich

Affiliations Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America , Center of Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

Stephen C Strom

Affiliation Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Erin Schuetz

Affiliation Department of Pharmaceutical Sciences, Saint Jude Children's Research Hospital, Memphis, Tennessee, United States of America

Thomas H Rushmore

Affiliation Drug Metabolism, Merck and Company, West Point, Pennsylvania, United States of America

Roger Ulrich

Affiliation Rosetta Inpharmatics, Seattle, Washington, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

EES, CM, AK, JL, FG, SCS, ES, THR, RU conceived and designed the experiments. EES, CM, AK, CS, DG, AVN, MM, TAD, AJL, RCS, RU performed the experiments. EES, CM, EC, KH, XY, PKL, BZ, SW, JZ, JM, SKS, DG, JD, JS, RCS analyzed the data. EES, CM, EC, KH, BZ, CS, JZ, JM, SKS, IA-C, MK, JMJ, CR, MM, TAD, AJL, FG, SCS, ES, THR, RU contributed reagents/materials/analysis tools. EES, CM, EC, KH, XY, PKL, AK, BZ, SW, JZ, JM, SKS wrote the paper.