About the Authors

Steven T Kosak

To whom correspondence should be addressed. E-mail: skosak@fhcrc.org (STK); markg@fhcrc.org (MG)

Affiliation Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

David Scalzo

Affiliation Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

Sam V Alworth

Affiliation SVision, Bellevue, Washington, United States of America

Fusheng Li

Affiliation Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

Stephanie Palmer

Affiliation Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

Tariq Enver

Affiliation MRC Molecular Haematology Unit, Oxford University, United Kingdom

James S. J Lee

Affiliation SVision, Bellevue, Washington, United States of America

Mark Groudine

To whom correspondence should be addressed. E-mail: skosak@fhcrc.org (STK); markg@fhcrc.org (MG)

Affiliations Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America , Department of Radiation Oncology, University of Washington School of Medicine, Seattle, Washington, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

STK conceived of the project with MG's assistance. STK, DS, and FL performed the bioinformatics analysis. STK, DS, and SP performed the hybridizations, image capture, and image processing for the analysis of chromosome organization. SVA and JSJL—in consultation with STK and DS—programmed and implemented the SVCell application for pattern recognition and image analysis. TE provided assistance in culturing the FDCPmix progenitors and analyzing the microarray data. STK and MG wrote the manuscript.