About the Authors

Yi-Chieh Nancy Du

To whom correspondence should be addressed. E-mail: duy@mskcc.org

Affiliation Program in Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Brian C Lewis

Address ¤ Current address: University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Affiliation Program in Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Douglas Hanahan

Affiliation Department of Biochemistry, University of California San Francisco, San Francisco, California, United States of America

Harold Varmus

Affiliation Program in Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

YND and HV designed the experiments. BCL generated RIP-tva transgenic mice and contributed to the general strategy. DH contributed to the general strategy and provided RIP-Tag transgenic mice, protocols, and advice. YND performed the research. YND wrote the paper with assistance from HV, and BCL and DH reviewed and helped to edit the paper.