About the Authors

Catherine I Lacayo

Affiliation Department of Biochemistry, Stanford University, Stanford, California, United States of America

Zachary Pincus

Affiliations Department of Biochemistry, Stanford University, Stanford, California, United States of America , Program in Biomedical Informatics, Stanford University, Stanford, California, United States of America

Martijn M VanDuijn

Affiliation Department of Bioengineering, University of California, Berkeley, California, United States of America

Cyrus A Wilson

Affiliation Department of Biochemistry, Stanford University, Stanford, California, United States of America

Daniel A Fletcher

Affiliation Department of Bioengineering, University of California, Berkeley, California, United States of America

Frank B Gertler

Affiliation Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Alex Mogilner

Affiliations Department of Neurobiology, Physiology and Behavior, University of California Davis, Davis, California, United States of America , Department of Mathematics, University of California Davis, Davis, California, United States of America

Julie A Theriot

To whom correspondence should be addressed. E-mail: theriot@stanford.edu

Affiliations Department of Biochemistry, Stanford University, Stanford, California, United States of America , Department of Microbiology and Immunology, Stanford University, Stanford, California, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

CIL and JAT conceived and designed the experiments. CIL and MMVD performed the experiments. CIL, ZP, CAW, and AM analyzed the data. ZP, CAW, DAF, FBG, AM, and JAT contributed reagents/materials/analysis tools. CIL, ZP, AM, and JAT wrote the paper. ZP wrote a methods section. FBG made an intellectual contribution. AM wrote mathematical methods, results, and interpretation.