About the Authors

João F Passos

Affiliations Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, United Kingdom , Center for Integrated Systems Biology of Ageing and Nutrition, University of Newcastle, Newcastle upon Tyne, United Kingdom

Gabriele Saretzki

Affiliations Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, United Kingdom , Crucible Laboratory, Life Knowledge Park, University of Newcastle, Newcastle upon Tyne, United Kingdom

Shaheda Ahmed

Affiliations Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, United Kingdom , Crucible Laboratory, Life Knowledge Park, University of Newcastle, Newcastle upon Tyne, United Kingdom

Glyn Nelson

Affiliations Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, United Kingdom , Center for Integrated Systems Biology of Ageing and Nutrition, University of Newcastle, Newcastle upon Tyne, United Kingdom

Torsten Richter

Affiliation Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, United Kingdom

Heiko Peters

Affiliation Institute of Human Genetics, International Centre for Life, University of Newcastle, Newcastle upon Tyne, United Kingdom

Ilka Wappler

Affiliation Institute of Human Genetics, International Centre for Life, University of Newcastle, Newcastle upon Tyne, United Kingdom

Matthew J Birket

Affiliation School of Clinical and Laboratory Sciences, University of Newcastle, Newcastle upon Tyne, United Kingdom

Graham Harold

Affiliation Crucible Laboratory, Life Knowledge Park, University of Newcastle, Newcastle upon Tyne, United Kingdom

Karin Schaeuble

Affiliation Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, United Kingdom

Mark A Birch-Machin

Affiliation School of Clinical and Laboratory Sciences, University of Newcastle, Newcastle upon Tyne, United Kingdom

Thomas B. L Kirkwood

Affiliations Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, United Kingdom , Center for Integrated Systems Biology of Ageing and Nutrition, University of Newcastle, Newcastle upon Tyne, United Kingdom

Thomas von Zglinicki

To whom correspondence should be addressed. E-mail: t.vonzglinicki@ncl.ac.uk

Affiliations Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, United Kingdom , Center for Integrated Systems Biology of Ageing and Nutrition, University of Newcastle, Newcastle upon Tyne, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

JFP, MABM, TBLK, and TvZ conceived and designed the experiments. JFP, GS, SA, GN, TR, HP, IW, MJB, GH, and KS performed the experiments. JFP, GS, HP, and TvZ analyzed the data. TvZ wrote the paper.