About the Authors

Véronique Calleja

Contributed equally to this work with: Véronique Calleja, Damien Alcor

Affiliation Cell Biophysics Laboratory, Lincoln's Inn Fields Laboratories, London Research Institute, Cancer Research UK, London, United Kingdom

Damien Alcor

Contributed equally to this work with: Véronique Calleja, Damien Alcor

Affiliation Cell Biophysics Laboratory, Lincoln's Inn Fields Laboratories, London Research Institute, Cancer Research UK, London, United Kingdom

Michel Laguerre

Affiliation Institut Européen de Chimie et Biologie, Pessac Cedex, France

Jongsun Park

Address ¤ Current address: Cell Signaling Laboratory, Cancer Research Institute, College of Medicine, Chungnam National University, Taejon, South Korea

Affiliation Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland

Borivoj Vojnovic

Affiliation Advanced Technology Development Group, Gray Cancer Institute, Mount Vernon Hospital, Northwood, United Kingdom

Brian A Hemmings

Affiliation Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland

Julian Downward

Affiliation Signal Transduction Laboratory, Lincoln's Inn Fields Laboratories, London Research Institute, Cancer Research UK, London, United Kingdom

Peter J Parker

To whom correspondence should be addressed. E-mail: peter.parker@cancer.org.uk (PJP); banafshe.larijani@cancer.org.uk (BL)

Affiliation Protein Phosphorylation Laboratory, Lincoln's Inn Fields Laboratories, London Research Institute, Cancer Research UK, London, United Kingdom

Banafshé Larijani

To whom correspondence should be addressed. E-mail: peter.parker@cancer.org.uk (PJP); banafshe.larijani@cancer.org.uk (BL)

Affiliation Cell Biophysics Laboratory, Lincoln's Inn Fields Laboratories, London Research Institute, Cancer Research UK, London, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

VC, DA, and BL were involved in the design and performed the FRET experiments. VC was responsible for the design of the molecular biology tools and performed the biochemical experiments. ML was responsible for the molecular modeling. JP, BAH, and JD provided DNA constructs. VC, DA, BV, and BL were responsible for the set-up and optimisation of two-photon FLIM. BAH and JD were involved in scientific discussions. PJP and BL supervised the project. VC, DA, PJP, and BL were involved in writing the manuscript.