About the Authors

Jeremiah J Faith

Contributed equally to this work with: Jeremiah J Faith, Boris Hayete

Affiliation Bioinformatics Program, Boston University, Boston, Massachusetts, United States of America

Boris Hayete

Contributed equally to this work with: Jeremiah J Faith, Boris Hayete

Affiliation Bioinformatics Program, Boston University, Boston, Massachusetts, United States of America

Joshua T Thaden

Affiliations Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America , Boston University School of Medicine, Boston, Massachusetts, United States of America

Ilaria Mogno

Affiliations Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America , Department of Computer and Systems Science A. Ruberti, University of Rome, La Sapienza, Rome, Italy

Jamey Wierzbowski

Affiliations Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America , Cellicon Biotechnologies, Boston, Massachusetts, United States of America

Guillaume Cottarel

Affiliations Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America , Cellicon Biotechnologies, Boston, Massachusetts, United States of America

Simon Kasif

Affiliations Bioinformatics Program, Boston University, Boston, Massachusetts, United States of America , Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America

James J Collins

Affiliations Bioinformatics Program, Boston University, Boston, Massachusetts, United States of America , Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America

Timothy S Gardner

To whom correspondence should be addressed. E-mail: tgardner@bu.edu

Affiliations Bioinformatics Program, Boston University, Boston, Massachusetts, United States of America , Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America

Competing Interests

A portion of this work was conducted in collaboration with Cellicon Biotechnologies. JJC and TSG are founders and shareholders in the company. GC and JW are also shareholders in the company. All data, results, and algorithms from this collaboration have been made publicly available.

Author Contributions

JJF, BH, JJC, and TSG conceived and designed the experiments. JJF, BH, JTT, IM, JW, and GC performed the experiments. JJF, BH, IM, SK, and TSG analyzed the data and contributed reagents/materials/analysis tools. JJF, BH, JTT, JJC, and TSG wrote the paper.