About the Authors

Lucy Malinina

Contributed equally to this work with: Lucy Malinina, Margarita L Malakhova

Affiliation Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Margarita L Malakhova

Contributed equally to this work with: Lucy Malinina, Margarita L Malakhova

Affiliation Hormel Institute, University of Minnesota, Austin, Minnesota, United States of America

Alex T Kanack

Affiliation Hormel Institute, University of Minnesota, Austin, Minnesota, United States of America

Min Lu

Affiliation Department of Biochemistry, Weill Medical College of Cornell University, New York, New York, United States of America

Ruben Abagyan

Affiliation Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America

Rhoderick E Brown

To whom correspondence should be addressed. E-mail: reb@umn.edu (REB); pateld@mskcc.org (DJP)

Affiliation Hormel Institute, University of Minnesota, Austin, Minnesota, United States of America

Dinshaw J Patel

To whom correspondence should be addressed. E-mail: reb@umn.edu (REB); pateld@mskcc.org (DJP)

Affiliation Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

LM, MLM, REB, and DJP conceived and designed the experiments. LM was responsible for x-ray data collection, analysis and structure determination. MLM was responsible for the biochemistry and crystallization, with biochemical assistance from ATK. ML was responsible for the ultracentrifugation experiments. RA was responsible for the ODA calculations. REB and DJP supervised and insured implementation of the project. LM, REB, and DJP wrote the paper with contributions from MLM, ML, and RA.