About the Authors

Christopher J Lowe

Affiliation Department of Organismal Biology and Anatomy, University of Chicago, Chicago, Illinois, United States of America

Mark Terasaki

Affiliation Department of Cell Biology, University of Connecticut Health Center, Farmington, Connecticut, United States of America

Michael Wu

Affiliation Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America

Robert M Freeman Jr.

Affiliation Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

Linda Runft

Affiliation Department of Molecular, Cellular, and Developmental Biology, University of California Santa Barbara, Santa Barbara, California, United States of America

Kristen Kwan

Affiliation Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

Saori Haigo

Affiliation Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

Jochanan Aronowicz

Affiliation Department of Organismal Biology and Anatomy, University of Chicago, Chicago, Illinois, United States of America

Eric Lander

Affiliations Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America , Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America , Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Chris Gruber

Affiliation Express Genomics, Frederick, Maryland, United States of America

Mark Smith

Affiliation Express Genomics, Frederick, Maryland, United States of America

Marc Kirschner

Affiliation Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

John Gerhart

To whom correspondence should be addressed. E-mail: gerhart@socrates.berkeley.edu

Affiliation Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

CJL, MK, and JG conceived and designed the experiments. CJL, MT, MW, LR, KK, SH, JA, MK, and JG performed the experiments. CJL, MK, and JG analyzed the data. CJL, RMF, EL, CG, and MS contributed reagents/materials/analysis tools. CJL, MK, and JG wrote the paper.