About the Authors
- Vlad C Seitan
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Affiliation Institute of Human Genetics, University of Newcastle, Newcastle upon Tyne, United Kingdom
- Peter Banks
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Affiliations Institute of Human Genetics, University of Newcastle, Newcastle upon Tyne, United Kingdom , Institute of Cell and Molecular Biosciences, University of Newcastle, Newcastle upon Tyne, United Kingdom
- Steve Laval
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Affiliation Institute of Human Genetics, University of Newcastle, Newcastle upon Tyne, United Kingdom
- Nazia A Majid
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Affiliation Institute of Human Genetics, University of Newcastle, Newcastle upon Tyne, United Kingdom
- Dale Dorsett
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Affiliation Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America
- Amer Rana
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Affiliation Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Zoology, University of Cambridge, Cambridge, United Kingdom
- Jim Smith
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Affiliation Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Zoology, University of Cambridge, Cambridge, United Kingdom
- Alex Bateman
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Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom
- Sanja Krpic
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Affiliation Erasmus Medical Center, University of Rotterdam, Rotterdam, Netherlands
- Arnd Hostert
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Affiliation Erasmus Medical Center, University of Rotterdam, Rotterdam, Netherlands
- Robert A Rollins
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Current address: Department of Oncology, Wyeth Research Pearl River, New York, United States of America
Affiliation Weill Graduate School of Medical Sciences, Cornell Medical College, New York, New York, United States of America
- Hediye Erdjument-Bromage
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Affiliation Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
- Paul Tempst
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Affiliation Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
- Claire Y Benard
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Current address: Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York, United States of America
Affiliation Department of Biology, McGill University, Montreal, Canada
- Siegfried Hekimi
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Affiliation Department of Biology, McGill University, Montreal, Canada
- Sarah F Newbury
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Affiliation Institute of Cell and Molecular Biosciences, University of Newcastle, Newcastle upon Tyne, United Kingdom
- Tom Strachan
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*To whom correspondence should be addressed. E-mail: tom.strachan@ncl.ac.uk
Affiliation Institute of Human Genetics, University of Newcastle, Newcastle upon Tyne, United Kingdom
Competing Interests
The authors have declared that no competing interests exist.
Author Contributions
DD initiated the Drosophila analyses that were done partly in collaboration with RAR, HEB, and PT. AR and JS were responsible for X. tropicalis analyses in collaboration with TS. AB and TS carried out PSI-Blast analyses. SK and AH contributed antibodies and unpublished data. CYB and SH provided C. elegans reagents and advised on the interpretation of the C. elegans data that were produced by PB under the supervision of SFN and TS. All other data were generated by VCS, SL, and NAM under the supervision of TS. The bulk of the paper was written by TS.