About the Authors

Jun Lu

Affiliations Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America , Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

Mischa Machius

Affiliation Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

Irina Dulubova

Affiliations Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America , Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

Han Dai

Affiliations Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America , Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

Thomas C Südhof

Affiliations Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America , Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America , Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

Diana R Tomchick

Affiliation Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

Josep Rizo

To whom correspondence should be addressed. E-mail: jose@arnie.swmed.edu

Affiliations Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America , Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

JL, MM, ID, HD, TCS, DRT, and JR conceived and designed the experiments. JL, MM, ID, HD, and DRT performed the experiments. JL, MM, ID, HD, DRT, and JR analyzed the data. JL contributed reagents/materials/analysis tools. JR wrote the paper.