About the Authors

Klaus Förstemann

Affiliation Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Yukihide Tomari

Affiliation Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Tingting Du

Affiliation Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Vasily V Vagin

Affiliation Institute of Molecular Genetics of RAS, Moscow, Russia

Ahmet M Denli

Affiliation Watson School of Biological Sciences, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America

Diana P Bratu

Affiliation Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Carla Klattenhoff

Affiliation Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

William E Theurkauf

Affiliation Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Phillip D Zamore

To whom correspondence should be addressed. E-mail: phillip.zamore@umassmed.edu

Affiliation Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

KF, YT, TD, VVV, WET, and PDZ conceived and designed the experiments. KF, YT, TD, VVV, DPB, CK, and WET performed the experiments. KF, YT, TD, VVV, DPB, CK, WET, and PDZ analyzed the data. KF, YT, TD, VVV, AMD, DPB, CK, WET, and PDZ contributed reagents/materials/analysis tools. KF, WET, YT, and PDZ wrote the paper.