About the Authors

Takaharu Okada

Contributed equally to this work with: Takaharu Okada, Mark J Miller

Affiliation Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, California, United States of America

Mark J Miller

Contributed equally to this work with: Takaharu Okada, Mark J Miller

Address Current address: Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America

Affiliation Department of Physiology and Biophysics, University of California, Irvine, California, United States of America

Ian Parker

Affiliation Department of Neurobiology and Behavior, University of California, Irvine, California, United States of America

Matthew F Krummel

Affiliation Department of Pathology, University of California, San Francisco, California, United States of America

Margaret Neighbors

Address Current address: Maxygen, Redwood City, California, United States of America

Affiliation Department of Immunobiology, DNAX Research Institute, Palo Alto, California, United States of America

Suzanne B Hartley

Address Current address: Ainslie, ACT, Australia

Affiliation Department of Immunobiology, DNAX Research Institute, Palo Alto, California, United States of America

Anne O'Garra

Address Current address: Laboratory of Immunoregulation, The National Institute for Medical Research, London, United Kingdom

Affiliation Department of Immunobiology, DNAX Research Institute, Palo Alto, California, United States of America

Michael D Cahalan

To whom correspondence should be addressed. E-mail: mcahalan@uci.edu (MC), Email: cyster@itsa.ucsf.edu (JC)

Affiliation Department of Physiology and Biophysics, University of California, Irvine, California, United States of America

Jason G Cyster

To whom correspondence should be addressed. E-mail: mcahalan@uci.edu (MC), Email: cyster@itsa.ucsf.edu (JC)

Affiliation Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, California, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

TO, MJM, MDC, and JGC conceived and designed the experiments. TO and MJM performed the experiments. TO, MJM, IP, MDC, and JGC analyzed the data. TO, MJM, IP, MFK, MN, SBH, AO, MDC, and JGC contributed reagents/materials/analysis tools. TO, MJM, IP, MDC, and JGC wrote the paper.